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Here with you to give kids more time to be kids

In JUNIPERA in biologic-naive patients with ERA

Longer time to flare in Treatment Period 21,9

Time to flare in ERA vs placebo (exploratory end point) did not reach statistical significance. Supplementary analyses provided confirmatory evidence of the treatment effect in ERA.1

In JUNIPERA, the primary end point was time to flare in Treatment Period 2 of the study in the combined JPsA and ERA patient population.9

Time to flare

Disease flare was defined as a ≥30% worsening in ≥3 of the 6 JIA ACR response criteria, and ≥30% improvement in ≤1 of the 6 JIA ACR response criteria and ≥2 active joints.1

JIA ACR response criteria consist of 6 core components9
JIA ACR response criteria consist of 6 core components

*During Treatment Period 2, a total of 6 patients with ERA in the COSENTYX® (secukinumab) arm experienced a flare event compared with 10 patients in the placebo arm.1
†Measured on a 100-mm VAS.9
‡Any joint with swelling or, in the absence of swelling, limitation of motion accompanied by either pain on motion or tenderness not due to deformity.9

*Limitations apply. Up to a $16,000 annual limit. Offer not valid under Medicare, Medicaid, or any other federal or state program. Novartis reserves the right to rescind, revoke, or amend this program without notice. Limitations may apply in MA and CA. For complete Terms and Conditions details, call 1-844-267-3689.

Definitions

ACR, American College of Rheumatology; CHAQ, Childhood Health Assessment Questionnaire; CI, confidence interval; CRP, C-reactive protein; ERA, enthesitis-related arthritis; HR, hazard ratio; JIA, juvenile idiopathic arthritis; JPsA, juvenile psoriatic arthritis; VAS, visual analog scale.

References

1. Cosentyx. Prescribing information. Novartis Pharmaceuticals Corp.

2. Humira. Prescribing Information. AbbVie Inc; 2021.

3. Orencia. Prescribing Information. Bristol-Myers Squibb Co; 2021.

4. Actemra. Prescribing Information. Genentech Inc; 2022.

5. Ilaris. Prescribing Information. Novartis Pharmaceuticals Corp; 2020.

6. Simponi Aria. Prescribing Information. Janssen Biotech Inc; 2021.

7. Xeljanz. Prescribing Information. Pfizer Inc; 2022.

8. Taltz. Prescribing Information. Eli Lilly & Co; 2021.

9. Data on file. CAIN457F2304 Clinical Study Report. Novartis Pharmaceuticals Corp; June 2020.

a. Baraliakos X, Gossec L, Pournara E, et al. Secukinumab in patients with psoriatic arthritis and axial manifestations: results from the double-blind, randomised, phase 3 MAXIMISE trial. Ann Rheum Dis. 2021;80(5):582-590.

b. Data on file. CAIN457F2342 (FUTURE 5): 2-Year Interim Report. Novartis Pharmaceuticals Corp; May 2019.

c. Data on file. CAIN457F2342 (FUTURE 5): 2-Year Interim Report PASI 90 and ACR Components data. Novartis Pharmaceuticals Corp; January 2020.

d. Data on file. CAIN457F2342 (FUTURE 5): 2-Year Interim Report mNAPSI and PASI 100 data. Novartis Pharmaceuticals Corp; October 2019.

e. Data on file. CAIN457H2315 Data Analysis Report. Novartis Pharmaceuticals Corp; April 2020.

f. Data on file. CAIN457H2315 Clinical Study Report. Novartis Pharmaceuticals Corp; November 2019.

g. Data on file. CAIN457F2310 Data Analysis Report. Novartis Pharmaceuticals Corp; June 2019.

h. Data on file. CAIN457F2310 (MEASURE 2): Nocturnal Back Pain. Novartis Pharmaceuticals Corp; February 2021.

i. Data on file. CAIN457F2342 (FUTURE 5): Interim Data Analysis Report FACIT-Fatigue data through Week 52. Novartis Pharmaceuticals Corp; April 2019.

j. Poddubnyy DA, Rudwaleit M, Listing J, Braun J, Sieper J. Comparison of a high sensitivity and standard C reactive protein measurement in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis. Ann Rheum Dis. 2010;69(7):1338-1341.

k. Data on file. CAIN457F2342 Clinical Study Report Interim Analysis-Week 24. Novartis Pharmaceuticals Corp; November 2017.

l. Data on file. CAIN457F2342 (FUTURE 5): 2-Year HAQ-DI biologic-naive data. Novartis Pharmaceuticals Corp; February 2021.

m. Cosentyx. Prescribing information. Novartis Pharmaceuticals Corp.

n. Data on file. Selected EAIRs MEASURE 2 Year 5. Novartis Pharmaceuticals Corp; January 2020.

o. Nash P, Mease PJ, McInnes IB, et al; on behalf of the FUTURE 3 study group. Efficacy and safety of secukinumab administration by autoinjector in patients with psoriatic arthritis: results from a randomized, placebo-controlled trial (FUTURE 3). Arthritis Res Ther. 2018;20(1):47.

p. Data on file. LTD Cosentyx Prescriber and Patient Counts. Novartis Pharmaceuticals Corp; July 2021.

q. Boonen A, Sieper J, van der Heijde D, et al. The burden of non-radiographic axial spondyloarthritis. Semin Arthritis Rheum. 2015;44(5):556-562.

r. Data on file. CAIN457F2304 Clinical Study Report. Novartis Pharmaceuticals Corp; June 2020.

s. Data on file. CAIN457F2304 Data Analysis Report. Novartis Pharmaceuticals Corp; January 2022.

t. Bodemer C, Kaszuba A, Kingo K, et al. Secukinumab demonstrates high efficacy and a favourable safety profile in paediatric patients with severe chronic plaque psoriasis: 52-week results from a Phase 3 double-blind randomized, controlled trial. J Eur Acad Dermatol Venereol. 2021;35(4):938-947.