Trust the efficacy and safety you know in the IV formulation your patients may need^1*

COSENTYX (for IV use) must be diluted prior to infusion. Using aseptic technique, prepare COSENTYX (for IV use) as follows:

Step 1:
Volume calculation

• Calculate the total volume of COSENTYX for IV use solution required based on the patient’s actual body weight as follows:

  • Loading dose is 0.24 mL/kg or 6 mg/kg

  • Maintenance dose is 0.07 mL/kg or 1.75 mg/kg

• Use the number of vials based on total volume needed (1 vial contains 5 mL or 125 mg of COSENTYX solution)

Step 2:
Dilution

• Allow the diluted COSENTYX solution for infusion to warm to room temperature prior to the start of the intravenous infusion 

• Parenteral drug product should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not use if particulates or discolorations are noted

• Follow the table below for recommended infusion-bag size based on patient’s body weight

Recommended infusion bags for dilution and preparation of COSENTYX for IV use based on body weight and dose

*If a 50-mL infusion bag is unavailable, then use a 100-mL infusion bag and withdraw and discard 50 mL of saline using aseptic technique and continue to follow the preparation and administration steps.

• From the infusion bag, withdraw and discard a volume of 0.9% Sodium Chloride Injection, USP equal to the calculated volume of the COSENTYX concentrate solution required for the patient’s dose

• From the vial(s), withdraw the calculated volume (mL) of COSENTYX solution and add slowly into the 0.9% Sodium Chloride Injection, USP infusion bag. To mix the solution, gently invert the bag to avoid foaming. Do not shake

• Discard unused COSENTYX product in vials because it does not contain preservatives

• Administer the diluted COSENTYX solution for infusion as soon as possible. If not administered immediately, store the diluted solution either:

  • At room temperature 20-25 °C (68-77 °F) for no more than 4.5 hours from the start of the preparation (piercing the first vial) to the completion of infusion

  • Under refrigeration at 2-8 °C (36-46 °F) for no more than 24 hours from the start of the time of the preparation (piercing the first vial) to the completion of infusion. This time includes the refrigeration of the diluted solution and the time to allow the diluted solution to warm to room temperature. Protect the diluted solution from light during storage under refrigeration

Step 3:
Administration

• Use only an infusion set with an in-line, sterile, nonpyrogenic, low-protein-binding filter (pore size 0.2 micrometer)

• Administer the infusion at a flow rate of about 3.3 mL/min for a 100-mL bag or 1.7 mL/min for a 50-mL bag (total administration time: 30 minutes)

• When administration is complete, flush the line with 0.9% Sodium Chloride Solution, USP to guarantee that all the diluted COSENTYX solution for infusion in the line has been administered 

• Do not infuse COSENTYX concomitantly in the same IV line with other drugs. No physical or biochemical compatibility studies have been conducted to evaluate the IV coadministration of COSENTYX with other drugs 

IV, intravenous; USP, United States Pharmacopeia.

An overview of the preparation and administration of the IV formulation of COSENTYX to help you infuse.